Animal Models in Cardiovascular Research - download pdf or read online

By David R. Gross D.V.M., Ph.D. (auth.)

ISBN-10: 9400950063

ISBN-13: 9789400950061

ISBN-10: 9401087172

ISBN-13: 9789401087179

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Additional resources for Animal Models in Cardiovascular Research

Example text

There were no changes in pulmonary artery pressures, right atrial pressures, aortic pressures or blood gases Same No cardiovascular information Resulted in precocious development thetic synaptic vesicles May function as calcium antagonist. 43 Guinea pigs 41 42 Heart rate increased at 5 and 15 min, no change at 30 and 60 min. Cardiac output increased at 5 and 15 min, no change at 30 and 60 min. No change in pulmonary, aortic or right atrial pressures. No change in blood gases or respiratory rate 2 2 53 Onset in about 10 min, with duration of about 1 hour.

Decreased chronotropic response not prevented by atropine. Occas. 1 mg dose imuced an increased chronotropic response followed by a decrease. Did not prevent effects of vagal stimulation or of ACH injected into the SA nodal artery Measured evoked tension, dose-dependent depression of contractile response to transmural electrical stimulation. Contractile response to norepinephrine not affected. 0 . 2 mg/kg every 1-2 hrs. Paralyzed with gallamine triethiodide (3mg/kg, IV) positive pressure ventilation provided.

Decreased firing rate of type B neurons in both the nucleus tractus solitarii and the nucleus ambiguus.

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Animal Models in Cardiovascular Research by David R. Gross D.V.M., Ph.D. (auth.)


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