Angiotensin II receptor antagonists : current perspectives - download pdf or read online
By Mancia Giuseppe
Considering angiotensin II is without doubt one of the such a lot effective vasoconstrictors and an enormous stimulus for the secretion of aldosterone from the adrenal gland, the improvement of of angiotensin II inhibitors is a vital step in regulating blood strain. This classification of drug is well-tolerated by way of pateints and those medicinal drugs have the extra virtue over ACE inhibitors in that they're no longer linked to cough. simply because such a lot medicines should be given as soon as day-by-day and, like ACEIs, they've got an invaluable additive hypotensive influence together with diuretics, they're a welcome healing instrument within the remedy of high blood pressure. This moment variation builds at the good fortune of the 1st and brings to the reader all of the newest advancements, scientific trial facts, and the contributors's own views while treating sufferers with angiotensin II receptors antagonists.
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Extra info for Angiotensin II receptor antagonists : current perspectives
Clinical overview of irbesartan: expanding the therapeutic window in hypertension. J Hypertens 1997; 15(Suppl 7):27–33. 33. Andersson OK, Neldam S. The antihypertensive effect and tolerability of candesartan cilexetil, a new generation angiotensin II antagonist, in comparison with losartan. Blood Press 1998; 7:53–9. 34. Sever P, Ménard J. Angiotensin II antagonism refined: candesartan cilexetil. A novel long-acting selective AT1-receptor blocker. J Hum Hypertens 1997; 11(Suppl 2):1–95. 35. White HD.
Eur J Pharmacol 1993; 247:139–44. 25. Shibouta Y, Inada Y, Ogima M et al. Pharmacological profile of a highly potent and long-acting angiotensin II-receptor antagonist, 2-ethoxy-1-[2Ј-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1Hbenzimidazole-7-carboxylic acid (CV 11974), and its prodrug, (Ϯ)-1-(cyclohexyloxycarbonyloxy)ethyl-2-ethoxy-1-[[2Ј-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116). J Pharmacol Exp Ther 1993; 266:114–20. 26. Dzielak DJ. Comparative pharmacology of the angiotensin II-receptor antagonists.
556 7/3/06 4:05 pm Page 25 Profiles of individual AT1 receptor antagonists 25 Eprosartan Eprosartan is a selective AT1 receptor antagonist. Its binding to AT1 receptors is reversible. 37 Its hemodynamic profile, antihypertensive efficacy, and tolerability are comparable with those of the other AT1 receptor antagonists. In pithed rats38 eprosartan inhibits the stimulated release of norepinephrine from presynaptic sites, probably via the blockade of presynaptic angiotensin receptors (AT1 type) on postganglionic sympathetic neurons.
Angiotensin II receptor antagonists : current perspectives by Mancia Giuseppe