New PDF release: An atlas of gynecologic oncology

By J. Richard Smith, Giuseppe Del Priore, Robert L. Coleman, John M. Monaghan, John Curtin

ISBN-10: 0203419545

ISBN-13: 9780203419540

ISBN-10: 0203444787

ISBN-13: 9780203444788

ISBN-10: 1853174904

ISBN-13: 9781853174902

(Martin Dunitz) manhattan Univ., long island urban. Atlas for postgraduates serious about the surgical administration of gynecological malignancy. contains a complete description of the vast majority of investigative and surgeries required of the gynecological oncologist. supplies transparent written and pictorial guide. comprises colour hand-drawn illustrations and photographs.

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Sample text

Elevated levels are seen in pregnancy and in benign liver disease. Serum levels are raised in most patients with liver tumours and in some with gastric, pancreatic, colon and bronchogenic malignancies (Onsrud 1991). In women with endodermal sinus tumours and embryonal carcinomas, AFP is a reliable marker for monitoring response to therapy and detecting recurrences (Chow et al 1996, Zalel et al 1996). It also accurately predicts the presence of yolk sac elements in mixed germ-cell tumours (Olt et al 1990).

Multivariate analysis identified preoperative CA125 levels as the most powerful prognostic factor for survival, the risk of dying of disease being 6 times higher in patients with CA125 elevation. Postoperative CA125 levels and measurements taken during chemotherapy have been found to be significant prognostic indicators. It is important to state here that in the immediate postoperative period CA125 levels can be elevated as a result of abdominal surgery (Yedema et al 1993a) and measurements should be postponed until just before chemotherapy is begun.

Gallion HH, Hunter JE, van Nagell JR et al (1992) The prognostic implications of low serum CA125 levels prior to the second-look operation for stage III and IV epithelial ovarian cancer, Gynecol Oncol 46:29–32. Gocze PM, Vahrson HW, Freeman DA (1994) Serum levels of squamous cell carcinoma antigen and ovarian carcinoma antigen (CA125) in patients with benign and malignant diseases of the uterine cervix, Oncology 51:430–4. Gold P, Freedman SO (1965) Specific carcinoembryonic antigens of the human digestive system, J Exp Med 122: 467–81.

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An atlas of gynecologic oncology by J. Richard Smith, Giuseppe Del Priore, Robert L. Coleman, John M. Monaghan, John Curtin

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