Download e-book for kindle: Aldol Reactions by Rainer Mahrwald

By Rainer Mahrwald

ISBN-10: 1402087004

ISBN-13: 9781402087004

ISBN-10: 1402087012

ISBN-13: 9781402087011

Aldol Reactions presents a accomplished updated evaluate of aldol reactions including:

  • Application of alternative steel enolates
  • Catalytic aldol additions catalyzed by way of diversified Lewis acids and Lewis bases
  • Enantioselective direct aldol additions
  • Antibodies and enzyme catalyzed aldol additions
  • The fresh competitive improvement of organocatalyzed aldol additions.

The strength of every procedure is confirmed by way of a number of functions in overall synthesis of average items. the professionals and cons of those methodologies with reference to stereoselectivity, regioselectivity and alertness in overall synthesis of common items are mentioned. nice significance is decided to the various chances of the guide of aldol response to put in required configurations in advanced normal product synthesis.

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Yan T, Tan C, Lee H, Lo H, Huang T (1993) J Am Chem Soc 115:2613 25. Xiang Y, Olivier E, Quimet N (1992) Tetrahedron Lett 33:457 26. Ahn KH, Yoo DJ, Kim JS (1992) Tetrahedron Lett 33:6661 27. Casper DM, Burgeson JR, Esken JM, Ference GM, Hitchcock SR (2002) Org Lett 4:3739 28. Gosh AK, Fidanze S, Onishi M, Hussain KA (1997) Tetrahedron Lett 38:7171 29. Gosh AK, Kim J (2001) Tetrahedron Lett 42:1227 30. Gosh AK, Kim J (2002) Tetrahedron Lett 43:5621 31. Ghosh AK, Onishi M (1996) J Am Chem Soc 118:2527 32.

Evans DA, Starr JT (2004) Angew Chem Int Ed 41:1787 69. Loh TP, Feng LC (2001) Tetrahedron Lett 42:6001 70. Jiang Y, Hong J, Burke SD (2004) Org Lett 6:1445 71. (a) Paterson I, Tudge M (2003) Angew Chem Int Ed 42:343; (b) Paterson I, Tudge M (2003) Tetrahedron 59:6833 72. Zou B, Wie J, Cai G, Ma D (2003) Org Lett 5:3503 73. Chen J, Forsyth CJF (2003) J Am Chem Soc 125:8734 74. 4 Titanium Enolates Titanium enolate-based aldol additions have a tremendous synthetic potential. 3 The titanium enolates were generated mostly by transmetallation of corresponding lithium enolates with ClTi(Oi-Pr)3 or ClTi(NR2)3.

8). 44 28 2 Aldol Reactions with Preformed Enolates 1. Et2BOTf, i-Pr2NEt 2. R1-CHO R1 N SO2 O 17 OH 1. Et2BOTf, i-Pr2NEt N SO2 O 2. 3 Boron Enolates 29 Tremendous comprehensive investigations on the stereochemical outcome of boron enolate aldol additions were carried out by Evans and coworkers. 45 and the references cited in it. 51 The great reliability of boron enolate aldol additions is reflected by numerous applications in total syntheses of polyketides. 52 Some examples illustrate the power of this method in natural product total synthesis.

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Aldol Reactions by Rainer Mahrwald

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