A Guide to Practical Toxicology: Evaluation, Prediction, and - download pdf or read online

By Woolley Adam

ISBN-10: 1420043145

ISBN-13: 9781420043143

This functional, common, and informative textual content surveys simple rules of toxicology. it truly is a useful consultant to comparing toxicity and comparable facts, imminent toxicity checking out and interpretation, and realizing the techniques of risk prediction and chance evaluation and administration.

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Extra resources for A Guide to Practical Toxicology: Evaluation, Prediction, and Risk

Example text

The fact that the molecule is not metabolized to a less toxic form but is regenerated, leaving it free to repeat the cycle many times, leads to depletion of NADPH with significant effects on cellular homeostasis. Paraquat also has effects in the kidney and other organs, but it is the lesion in the lung that is responsible for the death of the patient. The effect of the kidney change is to reduce renal function, slowing excretion, and thus exacerbating the toxicity. The mold Fusarium solani, found on sweet potatoes, produces 4-ipomeanol (Fig.

The expression of toxicity is influenced by factors inherent in the exposed subject, in addition to the factors listed in section “Strong Toxicants and Weak Toxicants,” including age, disease, pregnancy, genetics, nutrition, lifestyle, sex, and occupation. Metabolism The ability to metabolize and eliminate chemicals at the two extremes of age is, notably different to that seen during the majority of a lifespan. Neonates and geriatric people show different sensitivities to drugs due to differences in liver and kidney function; this can be extrapolated to other chemicals with which they may come in contact.

The original problem with digitalis extract, that of administering an imprecisely defined mixture of highly potent alkaloids with wide-ranging effects, has been gradually circumvented by purification and finally by synthesis of carefully targeted molecules. The effects of endogenous chemicals are, in some cases, mimicked by those of xenobiotics. Compounds such as opium and morphine have well-known addictive properties and share some properties with neuropeptides that are present naturally in mammals.

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A Guide to Practical Toxicology: Evaluation, Prediction, and Risk by Woolley Adam

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